Metabolomics in the diagnosis of sepsis

Metabolomics profiling and sepsis Works on metabolomics concerning sepsis conducted on animals and humans of different ages (newborn and adults) have recently been published and are presented in Table 1. In septic patients compared to controls (in plasma and urine) it is possible to observe an increase of metabolites which are part of the oxidative metabolism of fatty acids (such as hydroxybutyrate, acylcarnitines and acetoacetate). Briefly stated, alterations in the glucose metabolism in critical conditions can be seen as a redistribution of glucose consumption from the mitochondrial oxidative phosphorylation to other metabolic pathways, such as the production of lactate and the pentose phosphate pathway. In the study by Fanos et al. [7] a combined approach based on both nuclear magnetic resonance (1)H-NMR) and gas-chromatography-mass